Transcription factor Ikzf1 associates with Foxp3 to repress gene expression in Treg cells (Ichiyama-Sakaguchi G, in Immunity)
August 07, 2024
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The transcription factor Ikzf1 has been known to interact with Foxp3, the master transcription factor for regu […]
Continue Reading →Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases
January 05, 2024
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Yoshiaki Yasumizu, Naganari Ohkura (Graduate School of Medicine, Osaka University), and Shimon Sakaguchi (Expe […]
Continue Reading →Autoimmune range of TCR signaling
December 02, 2022
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The research group of Atsushi Tanaka (Graduate School of Medicine, Osaka University/IFReC) and Shimon Sakaguch […]
Continue Reading →How myasthenia gravis develops in thymoma patients? (Ohkura & Sakaguchi G, in Nat Commun.)
August 05, 2022
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Although Myasthenia gravis (MG) frequently develops in thymoma patients, the etiologic factors for MG are not […]
Continue Reading →A new mechanism of regulatory T cell generation
May 19, 2021
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A group of Shimon Sakaguchi (Experimental Immunology, IFReC) discovered the specific DNA elements, which are i […]
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