Detection of self-reactive CD8+ T cells with an anergic phenotype in healthy individuals (in Science)
December 19, 2014
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The authors found Treg can render self-reactive human CD8+ T cells anergic (i.e., hypoproliferative and cytoki […]
Continue Reading →Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease (in Science)
October 17, 2014
Tcells that mediate autoimmune diseases such as rheumatoid arthritis (RA) are difficult to characterize becaus […]
Continue Reading →”Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation (PNAS)” was published
March 27, 2014
Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcripti […]
Continue Reading →”Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans (PNAS)” was published
October 19, 2013
Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immun […]
Continue Reading →Sugiyama to receive “JACI Young Investigator Award”.
July 09, 2013
Japanese Association of Cancer Immunology (JACI) announced that Mr. Daisuke SUGIYAMA (Experimental Immunology […]
Continue Reading →Prof. Sakaguchi was Elected to “Distinguished Professor”
June 26, 2013
Osaka University (President: Toshio HIRANO) elected Shimon SAKAGUCHI (Deputy Dorector of IFReC) to “Dist […]
Continue Reading →Construction of self-recognizing regulatory T ce”lls from conventional T cells by controlling CTLA-4 and IL-2 expression (PNAS)” was published
June 04, 2013
Yamaguchi.T et al. Construction of self-recognizing regulatory T cells from conventional T cells by controllin […]
Continue Reading →“T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell development. (Immunity)” was published
November 18, 2012
The transcription factor Foxp3 is essential for the development of regulatory T (Treg) cells, yet its expressi […]
Continue Reading →Shimon Sakaguchi, Elected by National Academy of Sciences.
May 02, 2012
National Academy of Sciences (NAS) elected Professor Shimon Sakaguchi of IFReC to the foreign associate of NAS […]
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