{"id":366,"date":"2012-02-08T17:14:30","date_gmt":"2012-02-08T08:14:30","guid":{"rendered":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/?p=366"},"modified":"2013-08-26T04:04:53","modified_gmt":"2013-08-25T19:04:53","slug":"atl%e3%81%ab%e5%af%be%e3%81%99%e3%82%8b%e5%85%8d%e7%96%ab%e6%b2%bb%e7%99%82%e3%81%ab%e9%87%8d%e8%a6%81%e3%81%aa%e3%82%bf%e3%83%bc%e3%82%b2%e3%83%83%e3%83%88%e3%81%ab%e3%81%a4%e3%81%84%e3%81%a6","status":"publish","type":"post","link":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/?p=366","title":{"rendered":"\u897f\u5ddd\u51c6\u6559\u6388\u306eATL\u306b\u5bfe\u3059\u308b\u514d\u75ab\u6cbb\u7642\u306b\u91cd\u8981\u306a\u30bf\u30fc\u30b2\u30c3\u30c8\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c Blood \u306b\u63b2\u8f09"},"content":{"rendered":"<p>\u3000\u897f\u5ddd\u51c6\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u3088\u308aATL\u306b\u5bfe\u3059\u308b\u514d\u75ab\u6cbb\u7642\u306b\u91cd\u8981\u306a\u30bf\u30fc\u30b2\u30c3\u30c8(NY-ESO-1, MAGE-A3, MAGE-A4)\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c Blood \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>Nishikawa.H et al. Cancer\/testis antigens are novel targets of immunotherapy for adult T-cell leukemia\/lymphoma. Blood 119, 3097\u2013104 (2012).<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" style=\"display:block; margin-left:auto; margin-right:auto;\" src=\"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/wp-content\/uploads\/2013\/08\/nishikawa2.jpg\" alt=\"Nishikawa\" title=\"nishikawa.jpg\" border=\"0\" width=\"418\" height=\"600\" \/><\/p>\n<p>Abstract:<br \/>\nAdult T-cell leukemia\/lymphoma (ATLL) is an intractable hematologic malignancy caused by human T-lymphotropic virus type 1 (HTLV-1), which infects approximately 20 million people worldwide. Here, we have explored the possible expression of cancer\/testis (CT) antigens by ATLL cells, as CT antigens are widely recognized as ideal targets of cancer immunotherapy against solid tumors. A high percentage (87.7%) of ATLL cases (n = 57) expressed CT antigens at the mRNA level: NY-ESO-1 (61.4%), MAGE-A3 (31.6%), and MAGE-A4 (61.4%). CT antigen expression was confirmed by immunohistochemistry. This contrasts with other types of lymphoma or leukemia, which scarcely express these CT antigens. Humoral immune responses, particularly against NY-ESO-1, were detected in 11.6% (5 of 43) and NY-ESO-1-specific CD8(+) T-cell responses were observed in 55.6% (5 of 9) of ATLL patients. NY-ESO-1-specific CD8(+) T cells recognized autologous ATLL cells and produced effector cytokines. Thus, ATLL cells characteristically express CT antigens and therefore vaccination with CT antigens can be an effective immunotherapy of ATLL.<\/p>","protected":false},"excerpt":{"rendered":"<p>\u3000\u897f\u5ddd\u51c6\u6559\u6388\u306e\u30b0\u30eb\u30fc\u30d7\u3088\u308aATL\u306b\u5bfe\u3059\u308b\u514d\u75ab\u6cbb\u7642\u306b\u91cd\u8981\u306a\u30bf\u30fc\u30b2\u30c3\u30c8(NY-ESO-1, MAGE-A3, MAGE-A4)\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c Blood \u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 Nishikawa.H et al. Cance [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,5,10],"tags":[],"_links":{"self":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/366"}],"collection":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=366"}],"version-history":[{"count":9,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/366\/revisions"}],"predecessor-version":[{"id":429,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/366\/revisions\/429"}],"wp:attachment":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=366"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=366"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=366"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}