{"id":471,"date":"2014-03-27T22:18:26","date_gmt":"2014-03-27T13:18:26","guid":{"rendered":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/?p=471"},"modified":"2014-04-14T22:50:22","modified_gmt":"2014-04-14T13:50:22","slug":"%e6%a3%ae%e5%b7%9d%e6%b4%8b%e5%8c%a1%e3%81%95%e3%82%93%e3%81%ae%e5%88%b6%e5%be%a1%e6%80%a7t%e7%b4%b0%e8%83%9e%e3%81%ab%e3%81%8a%e3%81%91%e3%82%8bfoxp3%e3%81%a8%e3%82%a8%e3%83%94%e3%82%b2%e3%83%8e","status":"publish","type":"post","link":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/?p=471","title":{"rendered":"\u68ee\u5ddd\u6d0b\u5321\u3055\u3093\u306e\u5236\u5fa1\u6027T\u7d30\u80de\u306b\u304a\u3051\u308bFoxP3\u3068\u30a8\u30d4\u30b2\u30ce\u30e0\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c PNAS\u306b\u63b2\u8f09"},"content":{"rendered":"<p>\u68ee\u5ddd\u6d0b\u5321\u3055\u3093\u306e\u5236\u5fa1\u6027T\u7d30\u80de\u306b\u304a\u3051\u308bFoxP3\u3068\u30a8\u30d4\u30b2\u30ce\u30e0\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c PNAS\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002<\/p>\n<p>\n&nbsp;<br \/>\n<strong>Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation.<br \/>\nMorikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM Consortium.<br \/>\n<\/strong><br \/>\n<!--more--><br \/>\nProc Natl Acad Sci U S A. 2014 Apr 8;111(14):5289-94.<\/p>\n<p><strong>\u8981\u7d04:<\/strong><br \/>\n<br 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\/>\n\u3000Treg\u304a\u3088\u3073Tconv\u306e\uff34\u7d30\u80de\u6297\u539f\u30ec\u30bb\u30d7\u30bf\u30fc\uff08TCR\uff09\u523a\u6fc0\u524d\u5f8c\u306eRNA\u767a\u73fe\u30c7\u30fc\u30bf\u3092\u3001Cap analysis of gene expression (CAGE)\u6cd5\u306b\u3088\u308a\u53d6\u5f97\u3057\u305f\u3002Treg\u3067\u306f48,374\u500b\u3001Tconv\u3067\u306f45,705\u500b\u306e\u8ee2\u5199\u958b\u59cb\u70b9\uff08TSS\uff09\u3092\u691c\u51fa\u3057\u3001\u305d\u306e\u3046\u3061\u7d04\u534a\u6570\u306f\u672a\u77e5\u306eTSS\u3067\u3042\u3063\u305f\u3002Tconv\u306b\u6bd4\u3057\u3066Treg\u3067\u6709\u610f\u306b\u767a\u73fe\u30ec\u30d9\u30eb\u304c\u9ad8\u3044\u907a\u4f1d\u5b50\u7fa4\u3067\u306f\u3001Treg\u6a5f\u80fd\u767a\u73fe\u3092\u53f8\u308bIl2ra, Ctla4, Tnfrsf18\u3084Folr4\u7b49\u304c\u4e0a\u4f4d\u3092\u5360\u3081\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001TCR\u523a\u6fc0\u306b\u5bfe\u3059\u308b\u53cd\u5fdc\u306fTreg\u3068Tconv\u3067\u5927\u304d\u304f\u7570\u306a\u308a\u3001Treg\u3067\u306fTCR\u523a\u6fc0\u5f8c\u306e\u767a\u73fe\u6291\u5236\u304c\u591a\u304f\u306e\u907a\u4f1d\u5b50\u3067\u8a8d\u3081\u3089\u308c\u305f\u3002<br \/>\n\u3000\u6b21\u306b\u30b2\u30ce\u30e0\u5168\u4f53\u306b\u304a\u3051\u308bTreg\u3068Tconv\u306eDNA\u30e1\u30c1\u30eb\u5316\u72b6\u614b\u3092\u30e1\u30c1\u30eb\u5316DNA\u514d\u75ab\u6c88\u964d\u6cd5\u306b\u3088\u308a\u89e3\u6790\u3057\u305f\u3002Treg\u3067\u7279\u7570\u7684\u306b\u8131\u30e1\u30c1\u30eb\u5316\u3057\u3066\u3044\u308b\u9818\u57df (TSDR)\u306f\u308f\u305a\u304b301\u30ab\u6240\u3067\u3001\u534a\u6570\u4ee5\u4e0a\u306f\u907a\u4f1d\u5b50\u5185\u90e8\u306b\u96c6\u4e2d\u3057\u3066\u8a8d\u3081\u3089\u308c\u305f\u3002TSDR\u3068\u907a\u4f1d\u5b50\u767a\u73fe\u3068\u306e\u95a2\u4fc2\u3092\u89e3\u6790\u3059\u308b\u3068\u3001TSDR\u306e\u4e0a\u6d41\u306b\u3042\u308bTSS\u306fTconv\u306b\u6bd4\u3057Treg\u3067\u6709\u610f\u306b\u767a\u73fe\u304c\u9ad8\u304f\u3001Treg\u7279\u7570\u7684\u767a\u73fe\u3092\u793a\u3059\u907a\u4f1d\u5b50\u7fa4\u304c\u542b\u307e\u308c\u3066\u3044\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001TSDR\u304c\u3053\u308c\u3089\u306e\u907a\u4f1d\u5b50\u306eenhancer\u3068\u3057\u3066\u50cd\u3044\u3066\u3044\u308b\u53ef\u80fd\u6027\u3092\u793a\u5506\u3059\u308b\u3002\u3055\u3089\u306b\u3001TSDR\u3092\u3082\u3064\u907a\u4f1d\u5b50\u7fa4\u306f\u3001Foxp3-null Treg (Foxp3\u3092\u767a\u73fe\u3057\u306a\u3044Treg\u69d8\u7d30\u80de)\u3067\u3082Treg\u540c\u69d8\u306b\u767a\u73fe\u304c\u4ea2\u9032\u3057\u3066\u3044\u305f\u3002\u5373\u3061\u3001TSDR\u3092\u6301\u3064\u907a\u4f1d\u5b50\u7fa4\u306e\u767a\u73fe\u4e0a\u6607\u306f\u3001Foxp3\u975e\u4f9d\u5b58\u7684\u3067\u3042\u308b\u3068\u8003\u3048\u3089\u308c\u305f\u3002<br \/>\n\u3000\u6b21\u306bFoxp3\u306e\u7d50\u5408\u9818\u57df (Foxp3 BS)\u306b\u3064\u3044\u3066\u691c\u8a0e\u3057\u305f\u3068\u3053\u308d\u3001Foxp3 BS\u306f\u3001Treg\u3001Tconv\u306b\u5171\u901a\u306b\u767a\u73fe\u3059\u308b\u907a\u4f1d\u5b50\u306e\u907a\u4f1d\u5b50\u5185\u90e8\u304a\u3088\u3073\u30d7\u30ed\u30e2\u30fc\u30bf\u30fc\u9818\u57df\u306b\u8a8d\u3081\u3089\u308c\u305f\u3002\u8208\u5473\u6df1\u3044\u3053\u3068\u306b\u3001Foxp3 BS\u306fTreg-Tconv\u9593\u3067\u30af\u30ed\u30de\u30c1\u30f3\u72b6\u614b\u306b\u5dee\u306e\u8a8d\u3081\u3089\u308c\u306a\u3044\u9818\u57df\u306b\u96c6\u4e2d\u3057\u3066\u304a\u308a\u3001TSDR\u3068\u306e\u5171\u901a\u9818\u57df\u306f1\u30ab\u6240\u306e\u307f\u3067\u3042\u3063\u305f\u3002\u3053\u306e\u7d50\u679c\u306f\u3001Foxp3\u4f9d\u5b58\u7684\u8ee2\u5199\u8abf\u7bc0\u304c\u3001TSDR\u3068\u306f\u72ec\u7acb\u3057\u305f\u6a5f\u80fd\u3092\u6301\u3064\u53ef\u80fd\u6027\u3092\u610f\u5473\u3059\u308b\u3002\u307e\u305fFoxp3 BS\u306b\u95a2\u9023\u3057\u305f\u907a\u4f1d\u5b50\u306f\u3001TCR\u523a\u6fc0\u5f8c\u306b\u8ee2\u5199\u304c\u6291\u5236\u3055\u308c\u308b\u50be\u5411\u304c\u307f\u3089\u308c\u305f\u3002\u5373\u3061\u3001Treg\u7279\u7570\u7684\u306aDNA\u8131\u30e1\u30c1\u30eb\u5316\u9818\u57df\u306f\u3001TCR\u523a\u6fc0\u306b\u95a2\u4fc2\u306a\u304fTreg\u3067\u512a\u4f4d\u306b\u767a\u73fe\u3057\u3066\u3044\u308b\u907a\u4f1d\u5b50\u7fa4\u3068\u76f8\u95a2\u304c\u898b\u3089\u308c\u308b\u4e00\u65b9\u3001Foxp3 BS\u306f\u3001\u523a\u6fc0\u4f9d\u5b58\u6027\u306bTreg\u3067\u6291\u5236\u3055\u308c\u3066\u3044\u308b\u907a\u4f1d\u5b50\u3068\u76f8\u95a2\u304c\u898b\u3089\u308c\u3001\u4e21\u8005\u306b\u306f\u307b\u3068\u3093\u3069\u91cd\u8907\u304c\u8a8d\u3081\u3089\u308c\u306a\u304b\u3063\u305f\u3002<br \/>\n\u3000\u4ee5\u4e0a\u306e\u7d50\u679c\u3088\u308a\u3001Treg\u306e\u907a\u4f1d\u5b50\u767a\u73fe\u306fFoxp3\u4f9d\u5b58\u7684\u306a\u8ee2\u5199\u5236\u5fa1\u3068\u3001\u30a8\u30d4\u30b2\u30ce\u30e0\u306b\u95a2\u9023\u3057\u305fFoxp3\u975e\u4f9d\u5b58\u7684\u306a\u5236\u5fa1\u3067\u69cb\u6210\u3055\u308c\u308b\u3053\u3068\u304c\u660e\u3089\u304b\u3068\u306a\u3063\u305f\u3002<\/p>\n<p>\n<a onclick=\"javascript:pageTracker._trackPageview('\/outgoing\/www.pnas.org\/content\/early\/2013\/10\/11\/1316796110');\"  href=\"http:\/\/www.pnas.org\/content\/early\/2013\/10\/11\/1316796110\">LINK<\/a><\/p>\n<p><\/p>","protected":false},"excerpt":{"rendered":"<p>\u68ee\u5ddd\u6d0b\u5321\u3055\u3093\u306e\u5236\u5fa1\u6027T\u7d30\u80de\u306b\u304a\u3051\u308bFoxP3\u3068\u30a8\u30d4\u30b2\u30ce\u30e0\u306e\u5f79\u5272\u306b\u3064\u3044\u3066\u306e\u8ad6\u6587\u304c PNAS\u306b\u63b2\u8f09\u3055\u308c\u307e\u3057\u305f\u3002 &nbsp; Differential roles of epigenetic changes and Foxp [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3,5,10],"tags":[],"_links":{"self":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/471"}],"collection":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=471"}],"version-history":[{"count":4,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/471\/revisions"}],"predecessor-version":[{"id":511,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=\/wp\/v2\/posts\/471\/revisions\/511"}],"wp:attachment":[{"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=471"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=471"},{"taxonomy":"post_tag","embeddable":true,"href":"http:\/\/exp.immunol.ifrec.osaka-u.ac.jp\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=471"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}