A distinct subpopulation of CD25 negative T-follicular regulatory cells localizes in the germinal centers (Sakaguchi group, in PNAS)

Shimon Sakaguchi’s group (Experimental Immunology) and others have discovered that a specialized set of regulatory T-cells, T-follicular regulatory cells are able to display an unprecedented level of adaptability by compromising core parts of their regulatory T-cell identity in exchange for the ability to travel to a site of antibody production while still maintaining their core function as regulatory cells. This finding is important, as the discovery of these cells will allow their further study and understanding of their importance in disease pathology.