Shimon Sakaguchi (Experimental Immunology, IFReC) was elected the Thomson Reuters Citation Laureate 2015. The Laureates have been cited so often in the last two or more decades that these scientists typically rank in the top 0.1% in their research fields. The laureates are recognized

Prof. Shimon Sakaguchi won the 68th Chunichi Award, and the award ceremony was held on May 25. The Chunichi award was founded in 1947. The scientists and the artists affiliated with Nagoya city have been awarded. Prof. Sakaguchi won this award for “Research of immune regulation by reg

The Gairdner Foundation announced on March 25 that Prof Shimon Sakaguchi and the six other scientists are awarded The Canada Gairdner International Award 2015. The Canada Gairdner International Award is recognized as one of the most prestigious awards in biomedical sciences. The previ

The authors found Treg cells directly inhibited, via CTLA-4, B cell expression of CD80 and CD86, which was essential for Tfh cell formation. Article

The authors found Treg can render self-reactive human CD8+ T cells anergic (i.e., hypoproliferative and cytokine hypoproducing upon antigen restimulation) in vitro, likely by controlling the costimulatory function of antigen-presenting cells. Article

Tcells that mediate autoimmune diseases such as rheumatoid arthritis (RA) are difficult to characterize because they are likely to be deleted or inactivated in the thymus if the self antigens they recognize are ubiquitously expressed. One way to obtain and analyze these autoimmune T c

  Differential roles of epigenetic changes and Foxp3 expression in regulatory T cell-specific transcriptional regulation. Morikawa H, Ohkura N, Vandenbon A, Itoh M, Nagao-Sato S, Kawaji H, Lassmann T, Carninci P, Hayashizaki Y, Forrest AR, Standley DM, Date H, Sakaguchi S; FANTOM

  Anti-CCR4 mAb selectively depletes effector-type FoxP3+CD4+ regulatory T cells, evoking antitumor immune responses in humans. Sugiyama D, Nishikawa H, Maeda Y, Nishioka M, Tanemura A, Katayama I, Ezoe S, Kanakura Y, Sato E, Fukumori Y, Karbach J, Jäger E, Sakaguchi S. Experimen

Japanese Association of Cancer Immunology (JACI) announced that Mr. Daisuke SUGIYAMA (Experimental Immunology Lab, IFReC) is awarded “JACI Young Investigator Award 2013″.